The population geneticist Hampton L. Carson spent the major part of his career at Washington University (1949-1963) and the University of Hawaii (1963-1985) investigating the cytogenetics and evolution of Drosophila. As one of the major figures in the Hawaii Drosophila project, he made particularly important contributions to the study of speciation and selective and non-selective evolutionary mechanisms. The Carson Papers (1921-1993) contain correspondence, subject files, manuscripts of published and unpublished works by Carson, papers by colleagues and students, research notes, course materials, photographs, and biographical information, which documents Carson's career as an evolutionary geneticist. The collection is organized into nine series.

The collection includes three accessions: (1) a portion of Lewontin's correspondence files (mainly A-L) and copies of papers acquired in 1979; (2) a 2003 accession with files on various subjects and correspondence with about 30 colleagues, and (3) a substantial 2018 accession of about 60 linear feet that includes correspondence, manuscripts, and subject files. The topics discussed in the letters are numerous, including much on contemporary scientific controversies such as race, Darwin, evolution, intelligence, and biological determinism.